Hidrocortisona

Presentación

Succinato sódico de hidrocortisona 100 mg polvo — documentado: Apotex (FDA)

¿Para qué sirve hidrocortisona? Indicaciones autorizadas

INDICATIONS AND USAGE When oral therapy is not feasible, and the strength, dosage form, and route of administration of the drug reasonably lend the preparation to the treatment of the condition, the intravenous or intramuscular use of hydrocortisone sodium succinate for injection is indicated as follows: Allergic states: Control of severe or incapacitating allergic conditions intractable to adequate trials of…

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INDICATIONS AND USAGE When oral therapy is not feasible, and the strength, dosage form, and route of administration of the drug reasonably lend the preparation to the treatment of the condition, the intravenous or intramuscular use of hydrocortisone sodium succinate for injection is indicated as follows: Allergic states: Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment in asthma, atopic dermatitis, contact dermatitis, drug hypersensitivity reactions, serum sickness, transfusion reactions. Dermatologic diseases: Bullous dermatitis herpetiformis, exfoliative erythroderma, mycosis fungoides, pemphigus, severe erythema multiforme (Stevens-Johnson syndrome). Endocrine disorders: Primary or secondary adrenocortical insufficiency (hydrocortisone or cortisone is the drug of choice; synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infancy, mineralocorticoid supplementation is of particular importance), congenital adrenal hyperplasia, hypercalcemia associated with cancer, nonsuppurative thyroiditis. Gastrointestinal diseases: To tide the patient over a critical period of the disease in regional enteritis (systemic therapy) and ulcerative colitis. Hematologic disorders: Acquired (autoimmune) hemolytic anemia, congenital (erythroid) hypoplastic anemia (Diamond Blackfan anemia), idiopathic thrombocytopenic purpura in adults (intravenous administration only; intramuscular administration is contraindicated), pure red cell aplasia, select cases of secondary thrombocytopenia. Miscellaneous: Trichinosis with neurologic or myocardial involvement, tuberculous meningitis with subarachnoid block or impending block when used concurrently with appropriate antituberculous chemotherapy. Neoplastic diseases: For the palliative management of leukemias and lymphomas. Nervous System: Cerebral edema associated with primary or metastatic brain tumor, or craniotomy. Ophthalmic diseases: Sympathetic ophthalmia, uveitis and ocular inflammatory conditions unresponsive to topical corticosteroids. Renal diseases: To induce diuresis or remission of proteinuria in idiopathic nephrotic syndrome, or that due to lupus erythematosus. Respiratory diseases: Berylliosis, fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy, idiopathic eosinophilic pneumonias, symptomatic sarcoidosis. Rheumatic disorders: As adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in acute gouty arthritis; acute rheumatic carditis; ankylosing spondylitis; psoriatic arthritis; rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy). For the treatment of dermatomyositis, temporal arteritis, polymyositis, and systemic lupus erythematosus.

FDA (DailyMed) · Hydrocortisone sodium succinate · Indications and usage · texto original en inglés

Contraindicaciones de hidrocortisona

CONTRAINDICATIONS Hydrocortisone sodium succinate for injection is contraindicated in systemic fungal infections and patients with known hypersensitivity to the product and its constituents. Intramuscular corticosteroid preparations are contraindicated for idiopathic thrombocytopenic purpura. Hydrocortisone sodium succinate for injection is contraindicated for intrathecal administration. Reports of severe medical events have been associated with this route of administration.

FDA (DailyMed) · Hydrocortisone sodium succinate · Contraindications · texto original en inglés

Reconstitución de hidrocortisona

IV/IM: no más de 2 mL de agua bacteriostática o SF bacteriostático por vial de 100 mg.

Dilución de hidrocortisona

No diluir ni mezclar con otras soluciones (posibles incompatibilidades físicas).

Administración de hidrocortisona

IV lenta, infusión o IM.

Estabilidad y periodo de validez

Compatibilidad de hidrocortisona

Incompatible con

• No mezclar con otras soluciones

Conservación y protección de la luz

Polvo a 20–25 °C.

Apotex (FDA): conservar la solución reconstituida y/o diluida a 20–25 °C y protegida de la luz; usarla dentro de las 12 h. La etiqueta no indica explícitamente cubrir la bolsa o la línea durante la administración. Sin instrucción no significa que la protección sea innecesaria.

Advertencias

• La estabilidad tras reconstituir varía entre fabricantes: consultar la IPP y capturar el dato al validar esta ficha.

Diferencias entre fuentes oficiales

• La búsqueda en AEMPS devolvió Actocortina (otra sal de hidrocortisona), que no se usó porque su ficha no aplica al succinato.
• Corrección 0.9.0: se retiró la marca de protección durante la administración; la etiqueta Apotex la exige para conservar la solución reconstituida/diluida, sin instrucción explícita para la infusión.

Fuentes

1. FDA (DailyMed) · Hydrocortisone sodium succinateApotex Corp. · Succinato sódico, vial 100 mg polvo · versión 2026-07-28

Interacciones de hidrocortisona

3 medicamentos del catálogo con una interacción documentada en sus fichas oficiales. Abre cada una para ver el efecto, la recomendación y su fuente.

• Anfotericina BMayor
• FenitoínaModerada
• FenobarbitalModerada

Identificación

SNOMED CT (VTM)

16602005

RxNorm

5492