Lorazepam

Presentación

Solución 2 y 4 mg/mL — documentado: Hospira (FDA)

¿Para qué sirve lorazepam? Indicaciones autorizadas

INDICATIONS AND USAGE Status Epilepticus Lorazepam injection is indicated for the treatment of status epilepticus. Preanesthetic Lorazepam injection is indicated in adult patients for preanesthetic medication, producing sedation (sleepiness or drowsiness), relief of anxiety, and a decreased ability to recall events related to the day of surgery. It is most useful in those patients who are anxious about their surgical procedure and who would prefer to have diminished recall of the events of the day of surgery (see PRECAUTIONS, Information for Patients ).

FDA (DailyMed) · Lorazepam · Indications and usage · texto original en inglés

Dosis máximas y límites de lorazepam

Límites que la fuente establece para un contexto concreto. Una dosis recomendada no equivale a una dosis máxima; la posología completa por indicación, edad y peso está en la app.

Contraindicaciones de lorazepam

CONTRAINDICATIONS Lorazepam injection is contraindicated in patients with a known sensitivity to benzodiazepines or its vehicle (polyethylene glycol, propylene glycol, and benzyl alcohol), in patients with acute narrow-angle glaucoma, or in patients with sleep apnea syndrome. It is also contraindicated in patients with severe respiratory insufficiency, except in those patients requiring relief of anxiety and/or diminished recall of events while being mechanically ventilated. The use of lorazepam injection intra-arterially is contraindicated because, as with other injectable benzodiazepines, inadvertent intra-arterial injection may produce arteriospasm resulting in gangrene which may require amputation (see WARNINGS ). Lorazepam injection is contraindicated for use in premature infants because the formulation contains benzyl alcohol (see WARNINGS and PRECAUTIONS, Pediatric Use ).

FDA (DailyMed) · Lorazepam · Contraindications · texto original en inglés

Ajuste en insuficiencia renal

Patients with Renal Disease For acute dose administration, adjustment is not needed for patients with renal disease. However, in patients with renal disease, caution should be exercised if frequent doses are given over relatively short periods of time (see CLINICAL PHARMACOLOGY ).

FDA (DailyMed) · Lorazepam · Dosage and administration · texto original en inglés

Ajuste en insuficiencia hepática

Dose Administration in Special Populations Elderly Patients and Patients with Hepatic Disease No dosage adjustments are needed in elderly patients and in patients with hepatic disease.

FDA (DailyMed) · Lorazepam · Dosage and administration · texto original en inglés

Reconstitución de lorazepam

No requiere.

Dilución de lorazepam

Para uso IV, diluir con igual volumen de SF 0.9%, glucosa 5% o agua inyectable inmediatamente antes de administrar.

Administración de lorazepam

IV lenta (≤2 mg/min) o IM profunda.

Compatibilidad de lorazepam

Compatible con

• SF 0.9%
• Glucosa 5%

Conservación y protección de la luz

Refrigerar entre 2 y 8 °C.

Usar la caja para proteger el contenido de la luz.

Advertencias

• No usar si la solución tiene color o precipitado.
• Depresión respiratoria; antídoto: flumazenil.
• Contiene propilenglicol y alcohol bencílico (toxicidad en infusiones prolongadas o neonatos).

Fuentes

1. FDA (DailyMed) · LorazepamHospira, Inc. · Lorazepam 2 mg/mL y 4 mg/mL inyectable · versión 2026-07-10

Interacciones de lorazepam

3 medicamentos del catálogo con una interacción documentada en sus fichas oficiales. Abre cada una para ver el efecto, la recomendación y su fuente.

• Ácido valproico (valproato)Mayor
• HaloperidolMayor
• PregabalinaModerada

Identificación

SNOMED CT (VTM)

19225000

RxNorm

6470