Doxiciclina

Presentación

Polvo 100 mg — documentado: Slate Run (FDA)

¿Para qué sirve doxiciclina? Indicaciones autorizadas

INDICATIONS AND USAGE To reduce the development of drug-resistant bacteria and maintain the effectiveness of Doxycycline for Injection, USP and other antibacterial drugs, Doxycycline for Injection, USP should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in…

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INDICATIONS AND USAGE To reduce the development of drug-resistant bacteria and maintain the effectiveness of Doxycycline for Injection, USP and other antibacterial drugs, Doxycycline for Injection, USP should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy. Doxycycline for Injection, USP is indicated in infections caused by the following microorganisms: Rickettsiae (Rocky Mountain spotted fever, typhus fever, and the typhus group, Q fever, rickettsial pox and tick fevers). Mycoplasma pneumoniae (PPLO, Eaton Agent). Agents of psittacosis and ornithosis. Agents of lymphogranuloma venereum and granuloma inguinale. The spirochetal agent of relapsing fever ( Borrelia recurrentis ). The following gram-negative microorganisms: Haemophilus ducreyi (chancroid). Yersinia pestis. Francisella tularensis . Bartonella bacilliformis . Bacteroides species. Vibrio cholerae. Campylobacter fetus . Brucella species (in conjunction with streptomycin). Because many strains of the following groups of microorganisms have been shown to be resistant to tetracyclines, culture and susceptibility testing are recommended. Doxycycline is indicated for treatment of infections caused by the following gram-negative microorganisms when bacteriologic testing indicates appropriate susceptibility to the drug: Escherichia coli . Enterobacter aerogenes Shigella species. Acinetobacter species. Haemophilus influenzae (respiratory infections). Klebsiella species (respiratory and urinary infections). Doxycycline is indicated for treatment of infections caused by the following gram-positive microorganisms when bacteriologic testing indicates appropriate susceptibility to the drug: Streptococcus species Up to 44 percent of strains of Streptococcus pyogenes and 74 percent of Enterococcus faecalis have been found to be resistant to tetracycline drugs. Therefore, tetracyclines should not be used for streptococcal disease unless the organism has been demonstrated to be sensitive. For upper respiratory infections due to group A beta-hemolytic streptococci, penicillin is the usual drug of choice, including prophylaxis of rheumatic fever. Streptococcus pneumoniae . Staphylococcus aureus , respiratory, skin and soft tissue infections. Tetracyclines are not the drugs of choice in the treatment of any type of staphylococcal infections. Anthrax due to Bacillus anthracis , including inhalational anthrax (post-exposure): to reduce the incidence or progression of disease following exposure to aerosolized Bacillus anthracis . When penicillin is contraindicated, doxycycline is an alternative drug in the treatment of infections due to: Neisseria gonorrhoeae and N. meningitidis . Treponema pallidum and Treponema pertenue (syphilis and yaws). Listeria monocytogenes. Clostridium species. Fusobacterium fusiforme (Vincent's infection). Actinomyces species. In acute intestinal amebiasis, doxycycline may be a useful adjunct to amebicides. Doxycycline is indicated in the treatment of trachoma, although the infectious agent is not always eliminated, as judged by immunofluorescence.

FDA (DailyMed) · doxycycline hyclate · Indications and usage · texto original en inglés

Contraindicaciones de doxiciclina

CONTRAINDICATIONS This drug is contraindicated in persons who have shown hypersensitivity to any of the tetracyclines.

FDA (DailyMed) · doxycycline hyclate · Contraindications · texto original en inglés

Ajuste en insuficiencia renal

Studies to date have indicated that doxycycline hyclate at the usual recommended doses does not lead to excessive accumulation of doxycycline in patients with renal impairment.

FDA (DailyMed) · doxycycline hyclate · Dosage and administration · texto original en inglés

Reconstitución de doxiciclina

Según el fabricante, con agua inyectable o SF 0.9%.

Dilución de doxiciclina

SF 0.9% o glucosa 5% a 0.1–1 mg/mL.

Administración de doxiciclina

Infusión IV en 1–4 h.

Estabilidad y periodo de validez

Compatibilidad de doxiciclina

Compatible con

• SF 0.9%
• Glucosa 5%
• Ringer lactato (máx. 6 h)

Conservación y protección de la luz

Polvo a 20–25 °C.

PROTEGER DE LA LUZ. La solución tolera luz fluorescente 48 h, pero debe protegerse de la luz solar directa durante el almacenamiento y la infusión; la reconstituida refrigerada, de la luz solar y artificial.

Advertencias

• Fotosensibilidad cutánea en el paciente.

Fuentes

1. FDA (DailyMed) · doxycycline hyclateSlate Run Pharmaceuticals, LLC · Vial 100 mg polvo (hiclato) · versión 2026-06-23

Interacciones de doxiciclina

5 medicamentos del catálogo con una interacción documentada en sus fichas oficiales. Abre cada una para ver el efecto, la recomendación y su fuente.

• CarbamazepinaMayor
• WarfarinaMayor
• FenitoínaModerada
• FenobarbitalModerada
• RifampicinaModerada

Diagnósticos relacionados

Diagnósticos que la ficha técnica de doxiciclina menciona en sus indicaciones. Cada uno abre su definición y los demás medicamentos indicados.

• Carbunco (ántrax)
• Cólera
• Enfermedad de Lyme
• Gonorrea
• Gripe (influenza)
• Infecciones por Escherichia coli
• Infecciones por estafilococo
• Infecciones por estreptococo
• Infecciones por Haemophilus
• Infecciones por neumococo
• Listeriosis

Identificación

SNOMED CT (VTM)

10504007